Not known Details About Get Started
Not known Details About Get Started
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The undifferentiated nucleotide specificities of certain archaeal ligases have tantalizing implications for enzyme evolution as well as attainable use of ADP being a substrate by ancestors of modern DNA ligases. The power of some archaeal ligases to benefit from ATP and NAD+ or ATP and ADP as substrates is likely to be explained whenever they acknowledged just the ADP element frequent to all a few nucleotides.
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). The NTase area binds into the damaged and intact DNA strands in the foremost groove flanking the nick and also from the slight groove over the 3′-OH facet of the nick (supplemental Fig. S3). The OB domain binds throughout the slight groove to the face from the duplex at the rear of the nick.
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